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Study Offers Clues On Diet Benefits Without The Diet
Experiments which mimicked a low-calorie diet by tinkering with genes in mice extended their lives and prevented disease, and a drug that has the same effect could give people longer, healthier lives, scientists said on Thursday.
British researchers found that deleting a gene linked to nutrients and growth helped mice to live 20 percent longer on average, and partly explained why eating less appears to improve health and increase longevity.
The findings also offered a possible genetic drug target for protecting against aging-related diseases, they said.
“What we have shown is that this gene is one that regulates life span and also determines how healthy animals are in middle and late age,” said Dominic Withers of the Center for Diabetes and Endocrinology at University College London.
Withers and his colleagues used so-called knockout mice — mice bred with a certain gene removed or knocked out — in this case the ribosomal S6 protein kinase 1 (S6K1) gene.
Deleting S6K1 meant the mice’s bodies behaved in a similar way to mammals whose calorie intake is restricted, they said.
“These mice were resistant to type 2 diabetes … and they also appeared to have reduced incidence of the mouse-equivalent of osteoporosis — so they had stronger bones,” Withers said.
Balance, strength and coordination all improved in the knockout mice, and they were more inquisitive, suggesting their brains were healthier.
“Our results demonstrate that S6K1 influences healthy mammalian life span,” the researchers wrote in their study published in the journal Science.
Most calorie restriction studies have found that a lifetime of deprivation is needed to achieve the longer-life benefits, and many researchers are working on ways to replicate the findings with drugs.
Withers said he knew of various pharmaceutical companies looking at developing drugs that could manipulate the S6K1 pathway, and his study showed they may also prove useful in age-related diseases, assuming they are safe in the long term.
But he also noted that his study had shown that another well-known target, known as AMP-activated protein kinase or AMPK, was on the same pathway as S6K1, meaning existing drugs could be explored to see if they might have the same effect.
Metformin — a common diabetes drug that works by stimulating AMPK, a master circuit for energy metabolism in the body — could be examined in this context, he said.
Since people live far longer than mice, it is almost impossible to study fully the effects of restricting calories in humans, but this study in mice and another recently in monkeys offer good clues for humans, Withers said.
“The big implication is that intervening in aging protects against a broad spectrum of aging-related diseases, and there is now a druggable pathway providing a means to do this which could be used, in principle, in people,” he said.
Researchers reported in August that the antibiotic rapamycin, sold by Wyeth under brand Rapamune to suppress the immune system in transplant patients, showed promise at slowing age-related disease in older mice, but it is not clear how it works. By China Daily.
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Russia To Buy Warship From France In First Nato Arms Deal Since Cold War
Russia is close to buying a warship from France in its first deal to import military technology from a Nato state since the end of the Cold War.
Bernard Kouchner, France’s Foreign Minister, and Hervé Morin, the Defence Minister, made it clear that they supported the sale of a Mistral assault ship to Russia during talks in Moscow yesterday.
The move is likely to alarm other Nato states after Russia indicated that it was seeking a bigger deal to upgrade its armed forces with advanced Western technology. It could also raise tensions in the Black Sea, where Russia has threatened to act against Georgian naval vessels if they block ships from travelling to the separatist region of Abkhazia.
The Mistral can deploy four landing barges, 16 helicopters and up to 70 vehicles, including 13 tanks. It can also carry 450 soldiers and is equipped with a 69-bed hospital. The ship is likely to cost £350 million.
After a meeting of the Russian-French Security Cooperation Council Mr Morin said: “France is open to arms cooperation, including the possible sale of a helicopter ship to Russia.”
Mr Kouchner said that the two countries would have to reach a political agreement first but added: “If a political accord is reached I believe you will be able to buy this ship.”
General Nikolai Makarov, the chief of the Russian General Staff, has said that Moscow wants to buy up to four more ships of the same class to be jointly built in Russia.
Vladimir Popovkin, the Deputy Defence Minister, said last month that the Kremlin wanted the French ship because it was seeking technology to improve its own shipbuilding industry.
Mr Kouchner did not specify the terms of any political accord but the final decision will rest with President Sarkozy, who is likely to come under pressure from the United States not to sell advanced military hardware to Russia that could be used in any future conflict with Georgia.
Vladimir Vysotsky, Moscow’s naval commander, told reporters recently that Russia could have mobilised far more quickly in the Black Sea during last year’s war against Georgia if its navy had had a ship like the Mistral.
The plan has run into opposition from some within Russia’s defence establishment who argue that it undermines national security and harms domestic shipbuilding. It also marks a sea change in Russian defence procurement after decades when the Soviet Union relied on its own military technologies and was a major exporter of weaponry.
Russian shipbuilding is in dire need of modernisation. India is still waiting for delivery of a refitted aircraft carrier, the Soviet-era Admiral Gorshkov, under a contract signed in 2004. The vessel is two years late and is unlikely to be ready before 2012 after Russia almost doubled the price of refurbishment.
The Kremlin has embarked on a major overhaul of Russia’s Armed Forces but has already been forced to buy unmanned drone aircraft from Israel because domestic manufacturers lacked the capability to develop their own version.
The state arms monopoly, Rosoboronexport, expects to sell $6.5 billion (£4 billion) worth of military equipment this year but most of its customers are former Soviet states or countries that can not buy Western hardware.
It is also facing growing competition from China amid concern about the reliability of Russian products. Algeria tore up a contract with Russia in 2007 and returned 15 Mig-29 fighter jets after complaining about their “inferior quality”. By Tony Halpin, The Times.
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Fasting Carries Risk Of Overeating
The temptation to eat a lot during Ramadan, the Muslim holy month of fasting, is great, but Saiful Khandker makes a conscious effort to not overdo it.
“You just kind of have to be mindful of, OK, if I weren’t fasting and starving, what kind of meal would I have? And then kind of limit yourself based on that,” said Khandker, technology systems director for a hedge fund in New York.
Around the world, many observant Muslims like Khandker who’ve been fasting all day during Ramadan are thinking about the feast they’ll have on Eid al Fitr, the holiday that ends the holy month, next weekend. Khandker describes this day as the Muslim equivalent of Christmas, complete with gift exchanges for children and a lot of food — everyone can “pig out for the whole day.”
Food experts agree that the fast, during which observant Muslims refrain from eating during the day, can actually cause people to overeat. Some people actually take in more calories in one evening meal than they normally would over the course of a normal day during Ramadan, said Joe Regenstein, professor of food science at Cornell University in Ithaca, New York.
“Ironically, there are table manner rules in Islam, and they actually normally encourage you to leave the table partly hungry, which is consistent with modern health guidelines,” he said.
This is one of many quirks about religious dietary practices. While no specific regimen of the major religions is better or worse than any other, it is important to keep certain health issues in mind when following those rituals, experts say.
“My general take is that you can have good diets and bad diets in any of the religious systems,” Regenstein said.
Here is a sampling of dietary practices carried out in major religions today, and what you should know about them:
Fasting
Religious eating habits are especially relevant this month with Muslims observing Ramadan and Jews about to undertake an approximately 24-hour fast on Yom Kippur, which begins at sundown on September 27.
Overeating can harm the body and cause heartburn, cautioned Keri Gans, a registered dietitian in private practice in New York. If you are fasting, you should eat normal sized, well-balanced meals with plenty of liquids to avoid dehydration before a day without eating, she said.
Some people should generally not undertake fasts for health reasons, including pregnant or breastfeeding women and small children, Gans said. If you have an underlying condition such as diabetes, you should talk to your physician about whether you should fast.
As a part of a religion, fasting teaches discipline, Regenstein said.
“The discipline, at least in principle, should help a person eat better,” he said.
Meat laws
Kosher meat in Judaism is slaughtered in a specific way by a religious butcher known as a “shochet.” The animal is drained of blood and broiled or heavily salted to help remove the blood. Both Judaism and Islam, whose dietary laws fall under “halal,” mandate that the animal be ritually slaughtered with specific prayers.
The practice salting of meat helps fight bacteria, but probably not more than other modern antimicrobial techniques, Regenstein said.
“We’re talking about 4,000 years of salting having benefit, and the rest of the science, in a sense, has caught up in the last 10 years,” he said.
If sodium is a concern because of high blood pressure, there are butcher shops that sell meat with different kinds of salt, or unsalted meat for broiling.
The Jewish custom of separating milk and meat — not eating the two at the same meal and, for the most strict adherents, having separate plates and utensils for each — does not appear to have dietary advantages or disadvantages, experts say.
In a practical sense, this tradition forces people to make their meals more diverse and plan them out more carefully, Regenstein said. Usually, people will not eat as much meat overall when they practice this kosher separation, he said.
Hold the ham, shellfish
Judaism and Islam share a restriction against eating pork. Some say this helps stave off trichinosis, a parasitic disease that humans can get from eating undercooked or raw pork, Regenstein said. However, there is some question about whether pigs in the Middle East would have had trichinosis ages ago when these traditions were developed, he said.
In addition, Jews traditionally do not eat shellfish, such as shrimp. Again, there is some association with certain diseases, as well as pollution, but it’s not clear that this tradition leads to better health. Moreover, one of the staples of Jewish ritual meals such as Passover is gefilte fish, made from carp, which eats shrimp anyway, he said.
Attitudes to alcohol
The Muslim prohibition of alcohol is not necessarily good or bad, Gans said. There is some research to suggest that alcohol in moderation improves good cholesterol, but it is not definitive, she said. Red wine is associated with positive effects such as cancer prevention, but grape juice may offer the same benefits, Regenstein said. Moreover, avoiding alcohol also skirts the negative social implications associated with the substance.
In Judaism, however, wine is woven into ceremonies such as those for Passover and the Sabbath service. In fact, some synagogues give small portions of wine to children.
Vegetarianism
People who practice religions such as Buddhism are vegetarians to varying degrees, with some members electing to cut out dairy and eggs in addition to animals and fish. Some Hindus are also vegetarian, and generally consider cows to be sacred.
As long as vegetarians get an adequate supply of vitamins and protein, this can be a healthy lifestyle, Gans said. Some do need an extra boost iron or other nutrient, however, and should meet with a dietitian to figure out what’s best for them individually, Gans said.
A matter of taste?
This is just a smattering of traditions practiced by various groups today, and subgroups of the religions mentioned here may have specific additional restrictions on certain animals.
In the end, many religious dietary practices do not have any more impact on healthy eating than other habits that arise from personal preference, Gans said. Some people avoid shellfish because they simply do not like the taste, and do not get a determinant or benefit as a result.
But, said Regenstein, kosher and halal are not fundamentally sets of health laws. Though he follows kosher rules himself, as a teenager in a Jewish community in Newark, New Jersey, he was suspicious of the common wisdom that the milk and meat separation was healthier “because you don’t mix the bacteria.”
“When I got more formally involved, it was actually sort of nice to realize that in fact these are not health laws. They are in the official category of ‘God said, you do,’ and I don’t have to go back and try to chase this down.” By Elizabeth Landau, CNN.