Orange Corn May Reduce Blindness, Child Death

Decreasing or increasing the function of a newly discovered gene in corn may increase vitamin A content and have significant implications for reducing childhood blindness and mortality rates, according to a Purdue University-led study.

Torbert Rocheford, the Patterson Endowed Chair of Translational Genomics and professor of agronomy at Purdue, led the study that made findings in yellow and particularly orange corn, a type he said likely originated in the Caribbean and is popular in some Asian and South American countries as well as in northern Italy. The orange color comes from relatively higher levels of carotenoids, one of which is beta-carotene. Humans convert beta-carotene, which also is abundant in carrots, into vitamin A during digestion.

Rocheford is using simple visual selection for darker orange color combined with more advanced molecular natural diversity screening techniques to create better lines of the orange corn.

“We’re sort of turbocharging corn with desirable natural variation to make it darker and more nutritious,” Rocheford said.

Between 250,000 and 500,000 children – mostly in Africa and Southeast Asia – go blind each year because of vitamin A deficiency, according to the World Health Organization. Half of those children will die within a year of going blind. Rocheford said increasing beta-carotene levels in cereal grains, such as corn, is an economical approach to addressing these deficiencies in developing countries.

Rocheford said the gene beta-carotene hydroxylase 1 (crtR-B1) alters beta-carotene in corn in a way that reduces pro-vitamin A activity. Through a process known as hydroxylation, beta-carotene is converted into other carotenoids that can cut the amount of pro-vitamin A that is created through digestion in half, or eliminate it altogether. Reducing the function of the crtR-B1 gene would reduce hydroxylation considerably.

“Because of this, selecting a form of the gene that does not have much activity causes beta-carotene to build up,” said Rocheford, whose findings were published in the journal Nature Genetics. “We have started to move the favorable ‘weak’ allele into breeding materials.”

Conversely, “strong alleles” increasing crtR-B1 function boost the hydroxylation process, which creates more zeaxanthin. Zeaxanthin is a micronutrient that could protect against macular degeneration, the leading cause of blindness in people over 55 in Western industrialized nations, according to the American Macular Degeneration Foundation.

Zeaxanthin makes up 75 percent of the central macula in human eyes, according to the AMDF, and data show that macular pigment increases through dietary supplements.

Rocheford said the findings are encouraging for addressing problems in both developed and developing nations.

“It’s like a designer gene. We can select one version for the U.S. population to increase zeaxanthin and a different version to increase beta-carotene for the needs of the developing world,” he said.

Rocheford’s research will continue to look for ways to improve the nutrient profile of orange corn through simple visual selection and more advanced DNA and compound analyses. He said further efforts would focus on other genes that also hold promise to increase pro-vitamin A in corn.

Another challenge, he admits, would be introducing a new variety of corn to consumers.

“The U.S. only grows yellow and white corn, and Africa largely grows white corn,” Rocheford said. “But parts of the world – some parts of Asia and South America – actually prefer orange corn.”

Rocheford recently returned from a meeting in Zambia and saw an initial indication of consumer acceptance of orange corn there. He also stopped in northern Italy where orange corn is used for polenta, a sign that acceptance is possible in the developed world as well.

The U.S. Agency for International Development and HarvestPlus funded Rocheford’s contributions to the research. Other agencies, such as the U.S. Department of Agriculture and the National Science Foundation funded the research of Rocheford’s collaborators.

Rocheford worked with researchers at CIMMYT, USDA Agricultural Research Service, Boyce Thompson Research Institute, Cornell University and Michigan State University. redOrbit

Success Through Management Training

Many customers today have forgotten the fact what it was like to be treated as someone special. We have seen a lot of companies and establishments who haven’t exerted more efforts to possibly uplift Customer Service training as one of their tools in turning it into an all-around better, more successful company. These are things most likely people have forgotten or simply just don’t care about it. Listening to your customers, even or especially when they are angry is so very important. And only when you truly understand your customer’s issues and needs can you find a workable solution.

Meanwhile, Management Training within many leadership development programs, wise organizations develop a series of competencies that are necessary to master in an effort to achieve success in supporting the companies’ strategic goals. Through training, these skills may require considerable time to master at an observable level. Budding leaders are often placed in a series of field and intense training to foster a command of competency and build capacity in its use. The training is kept fairly standard to ensure the entire population of leaders has the same opportunity to achieve success.

Under the current economic environment most businesses are finding making sales not as easy as it used to be. Then there is the problem of getting customers off the fence to make a decision and move forward. It is no wonder that many organizations complain of reduced closing ratios among a very competitive marketplace. Thus, learning how to create value for mutual gain, and build profitable long-term relationships through medical device sales training is one of the best options. As the process of having such, not only increases sales, improves productivity, enhances customer relations, but also catapults personal achievement drive.

Could Multivitamins Raise Breast Cancer Risk?

Many people take multivitamins in the hopes of thwarting disease, but a new study finds that older women who use multivitamins may be more likely than non-users to develop breast cancer.

The study, reported in the American Journal of Clinical Nutrition, points only to an association between multivitamin use and breast cancer. It does not prove that the supplements directly contribute to the disease.

However, the researchers say, it’s biologically plausible that multivitamins could have such an effect, and the potential link “merits further investigation.”

The findings come from a decade-long study of more than 35,000 Swedish women who were between the ages of 49 and 83 and cancer-free at the outset. Over an average of 10 years, 974 women were diagnosed with breast cancer.

Researchers found that women who reported multivitamin use at the study’s start were 19 percent more likely than non-users to develop breast cancer. That was with factors like age, family history of breast cancer, weight, fruit and vegetable intake, and exercise, smoking and drinking habits taken into account.

Still, the large majority of multivitamin users did not develop breast cancer during the study period. Of 9,017 users, 293 were diagnosed with the disease, as were 681 women among the 26,000-plus who did not use multivitamins.

And while the study points to a generally higher risk of breast cancer among multivitamin users as a whole, the risks to any individual woman would likely be small.

“If the association is causal, using multivitamins would have a modest effect on breast cancer risk for any one woman,” lead researcher Dr. Susanna C. Larsson, of the Karolinska Institute in Stockholm, told Reuters Health in an email.

But given the widespread use of multivitamins, any potential risks are of “great public health importance,” the researchers say.

In the U.S., for example, it’s estimated that half of adults routinely use a dietary supplement, often a multivitamin. And studies show that one of the primary motivations is the belief that supplements will protect them from chronic diseases.

But a recent study of more than 160,000 older U.S. women found that over eight years, those who took multivitamins were no less likely than non-users to die of heart disease or cancer, with all cancers lumped together in a group.

The current study included more than 35,000 women who were surveyed about their multivitamin use, as well as a number of other health and lifestyle factors. It’s possible, according to Larsson, that factors the study did not measure could explain the association between multivitamins and breast cancer.

On the other hand, there are biologically plausible reasons that multivitamins themselves could be to blame, the researcher said. A recent study found that among premenopausal women, multivitamin users tended to have greater breast density than non-users — meaning the breasts have relatively less fat and more glandular and connective tissue. Greater breast density is linked to a relatively higher risk of breast cancer.

It’s not clear from that study, however, whether multivitamins themselves somehow boost breast density.

Another possibility, according to Larsson’s team, could be the B vitamin folic acid, which animal research has linked to breast cancer. Human studies, however, have come to various conclusions; while one found a higher risk of breast cancer among women who took folic acid supplements, others have linked the vitamin to either no effect on breast cancer risk, or a decreased risk.

Since multivitamins are, by definition, a mix of vitamins and minerals, it is difficult to pinpoint which nutrient, of combination of nutrients, may be particularly tied to breast cancer risk, the researchers point out.

Until more is known, a woman’s best bet is to get her vitamins and minerals from a well-balanced diet rather than pills, Larsson advised.

“If you eat a healthy and varied diet,” she said, “there is no need to use multivitamins.”  By Amy Norton, Yahoo Daily News

2010 Fitness Trends

Every year, millions of people set health and fitness goals and they tend to be the same, namely, the everlasting search for long lean muscles, less body fat, more energy, flexibility… 2010 is no different and has already ushered in three “new” fitness techniques and products that are hoping to one-up 2009’s international successes with efficiency.

Bellyfit

This is going after the female Zumba crowd. Originating in Canada, Bellyfit classes are women-only and are split into two sections. The first half is a melange of cardio dance including: belly dance, Bollywood, Bhangra, and African dance. The class then focuses on core strengthening and mind-body with various movements from Pilates, yoga and mudra meditation.

Bellyfit is actively training health and fitness professionals in Canada to expand Bellyfit to a gym near you.

Body by Science

This is the ultimate American invention promising complete body fitness in only 12 minutes a week. Doug McGuff, M.D., co-author of Body by Science and emergency room physician, created a research-based program for strength training, bodybuilding and complete fitness. The entire program requires rethinking everything you thought you knew about health, fitness and the science of your body.

Ultimate resistance training, slow movements, heavy weights, push you to your limits for exactly 12 minutes. According to Dr. McDuff, the 12-minute limit is not a marketing ploy, it is all the body can take.

ViPR

The ViPR (Vitality, Performance and Reconditioning) created in England boasts that it is the Swiss Army knife of exercise tools with the ability to integrate into 9,000 different exercises. Many are demonstrated on YouTube and ViPR-fit.com.

Proponents claim it can replace the barbell, dumbbell, Kettlebell, stability ball, medicine ball, balance device and speed ladder.

Some British trainers have said the ViPR offers a whole body workout in the same vein as The Power Plate. The Times of India

Why Are You Losing Weight?

Having dealt with women wanting to lose weight over the last 10 years, I often ask and am asked these questions:

How does being overweight affect society at large and vice versa?

How does society react to you individually when you lose weight?

How does social pressure influence your decisions to lose weight?

The whole idea of losing weight to fit into social norms has taken on a whole new dimension. What with some airlines ruling that obese passengers need to pay for two seats if the flight is full, to insurance companies insisting on a higher premium for clinically obese people who are known to have a higher health risk, being overweight is now not only unacceptable but also expensive. There is more pressure to lose the extra weight for social and economic reasons as well as cosmetic and wellbeing.

Women of the higher socio-economic strata in developed countries are less likely to be obese perhaps due to social pressure to remain slim and also the availability and affordability of nutritious rather than junk food.

Social response

Some women tell me that losing weight is hard enough; they also have to contend with (well meaning?) friends and relatives who take the liberty of commenting on their new improved appearance, sometimes not very encouragingly.

Some of the comments take on a complicated edge, “you look gaunt’, “you have lost too much weight” and, sometimes even, “you have lost your charm”. Other optimistic confidants insist that being plump suits you or reason that, after all, being overweight runs in the family and so there really isn’t much you can do about changing your genetic inclination.

What could possibly provoke these comments? Perhaps discomfort with one woman’s aptitude for change, to stay motivated and the admittance of one’s own inability to do so.

As one of my clients said, the fact that some of us are “approval addicts” can make it an arduous task to disregard such comments and forge ahead in pursuit of a healthier body.

On the other hand, gaining the admiration of those around you is definitely a catalyst for further improvement. We are all social beings. Appreciation from significant (and sometimes even not so significant) others is meaningful. This is where the right kind of encouragement during the process of change is critical to success.

Understand yourself

It’s an ongoing process of self-discovery. Losing weight is not just about losing the layers of fat. There is also a certain unravelling of one’s persona along with it.

We need to first appreciate our own sense of self, both from a physical and emotional perspective. How we categorise our own selves is crucial to our growth. Sometimes we see ourselves solely as “a fat person”, or “a physically unattractive person” forgetting there is more to that “person” than size and appearance.

As Gloria Steinem once said, “In my own mind, I am still a fat brunette from Toledo, and I always will be”. Chances are you too continue to think like you did before you lost all the weight and can barely see your altered self. This myopic vision is often a way of trying to ease the trauma of ‘change’ from within in addition to the distorted or altered behaviour of people around you.

Changing how we look also requires that we change how we think about ourselves. We need to recognise whether our entire identity resides with our physical appearance or if we have other outlets for our creativity and selfhood.

As women, I believe the pressure to be attractive is enormous. Wanting and trying to improve one’s appearance is different from depending totally on physical attributes to quantify oneself. Although there is absolutely nothing wrong or self-indulgent about desiring to look better, how and why you go about it is fundamental to determining if the change will be lasting and satisfying or only another step towards further turmoil.

In this context, unhealthy starvation diets, abusing and disrespecting the body will be counter-productive not only to health but also to one’s self-esteem.

It is true (and research has proven), that being emotionally troubled or stressed has a critical impact on our physical selves and vice versa. Women, in particular, are susceptible to external factors like opinions of others, suggestions and advice. Perhaps we are more insecure as a species or just more accommodating to social pressure.

There is often a deep-rooted difficult psychological background for most overweight women. It is not as simple as “jump on the treadmill and shed those pounds”. Although doing just that solves half the problems, including elevating one’s mood, following through is not as straightforward as it may seem. This is why, psychological counselling along the way helps stay on track.

Motivation, approval, denial, low self-esteem etc play a role in the state of one’s body.

Motive

So it comes down to this: What (or who) are you losing weight for?

Identification of your own motive is the first and foremost pre-requisite before starting on any kind of self improvement campaign, be it weight loss, improving posture, eating healthy, giving up alcohol and nicotine and so on. Often the very objective of the exercise is questionable.

Social pressure aside, it is necessary to delve into one’s own mind to identify reasons for wanting change. If these reasons don’t stand up to scrutiny, the results are often not sustainable.

One’s own actions and thoughts sometimes prevent change. Fear of stepping out of one’s comfort zone, in this case, being overweight and being accepted as or labelled as an “overweight person” may find one self-sabotaging one’s diet or attempts at regular exercise.

Question your reasoning when you find yourself making excuses to exercise. Is it fear of failure or fear of success?

Losing weight does not happen in a vacuum. There will be repercussions from within yourself and those around you. Knowing what you really want is important to keep you focused and motivated and understanding your true requirements will help you perhaps be more indulgent of uncalled for advice. As you know change is never easy, even if for the better.

A Healthy Diet May Trim Women’s Breast Cancer Risk

A woman can’t change her family history of breast cancer but she may be able to trim her chances of getting the disease by eating more vegetables and whole grains and drinking less alcohol, according to a new study.

An analysis of 18 published studies involving 400,000 people conducted by Queen’s University, Belfast in Northern Ireland, found there was an 11 per cent lower risk of breast cancer among women in the highest versus lower categories of a prudent diet.

Those consuming larger amounts of wine, beer and spirits had a 21 per cent increased risk of breast cancer, according to the analysis published in the American Journal of Clinical Nutrition.

“As the incidence of breast cancer continues to rise, with many of the risk factors for the disease non-modifiable, potentially modifiable risk factors such as diet are of interest,” said researcher Dr Sarah Brennan.

But Brennan said these findings had to be interpreted cautiously as there are inherent statistical problems in combining the results of multiple studies, in addition to the limitations of each included study, such as recall bias.

It is estimated that more than 120 out of every 100,000 American women are diagnosed with breast cancer each year, yielding a lifetime risk of about one in eight. The idea that diet might influence these numbers is not new but solid evidence for such a link has remained elusive with individual studies often too small to uncover modest relationships.

The studies used in the analysis aimed to associate breast cancer risks with at least one common dietary pattern: the “unhealthy” Western diet (high in red meats and refined grains), a more prudent “healthy” diet (high in fruits, vegetables and whole grains), or varying levels of alcohol drinking. No overall risk difference was seen between high and low categories of the Western diet. Mumbai Mirror

List of Social Ills Blamed on Facebook

Social networking site Facebook has been blamed for many social ills, the latest allegation being: it has led to a resurgence of the sexually transmitted disease syphilis.

Now, Telegraph has come up with a list of problems the site has been linked to:

1. Facebook leads ‘children to suicide’

Archbishop Vincent Nichols from the Catholic Church in England and Wales, claimed that Facebook reduced friendship to just a “commodity”. Because of the “transient nature” of it, teenagers become more prone to suicide when their networks collapse.

2. Facebook ‘killing off traditional sayings’

The site has been blamed for the slow death of British sayings such as “a little birdie told me” and “hold your horses”. In a survey on communication trend researchers found phrases commonly used by parents and grandparents were disappearing.

3. Facebook blamed for ‘rickets surge’

Facebook has been linked to the rise in the number of children suffering from rickets. Researchers wrote in the British Medical Journal that the social networking site, and computer games had led to the disease, caused by chronic vitamin D deficiencies. It occurs because of sitting for long periods out of natural sunlight and a poor diet.

4. Facebook ‘turning Britons into introverts’

A study from Mintel, the market research company, found more than half of adults who use sites such as Facebook admitted they spent more time chatting online than they did actually speaking to friends and family.

5. Facebook ‘makes partners jealous’

University of Guelph researchers found Facebook use led to increased jealousy in relationships, amid greater social exchanges with friends and previous partners. Lovers often get suspicious when their partners get hooked to the site.

6. More middle-aged people ‘learning to love’ Facebook

Ofcom, the communications regulator, found more middle-aged people are logging on to social networking sites such as Facebook in ever larger numbers. The number of 35 to 54-year-olds, using social networking sites, have increased by 25% in just one year.

7. Facebook makes users ‘feel unattractive’

Some Facebook users avoid uploading photos because they think they are too fat, old or ugly. A survey found almost one in two people admitted to leaving out pictures from their “fat days” when uploading pictures to their online profile. DNA India